Bioavailability and efficacy of antisens
โ
Vikram Arora; Derek C. Knapp; Muralimohan T. Reddy; Dwight D. Weller; Patrick L.
๐
Article
๐
2002
๐
John Wiley and Sons
๐
English
โ 199 KB
Antisense phosphorodiamidate Morpholino oligomers (PMO) are resistant to degradation by cellular hydrolases, DNases, RNases, and phosphodiesterases, but remain sensitive to prolonged exposure to low pH. The present studies evaluate the oral fractional bioavailability, stability, and efficacy of two