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Transdermal Use of Phosphorodiamidate Morpholino Oligomer AVI-4472 Inhibits Cytochrome P450 3A2 Activity in Male Rats

โœ Scribed by Vikram Arora; Tracy L. Hannah; Patrick L. Iversen; Rhonda M. Brand


Book ID
110395792
Publisher
Springer US
Year
2002
Tongue
English
Weight
158 KB
Volume
19
Category
Article
ISSN
0724-8741

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Antisense phosphorodiamidate Morpholino oligomers (PMO) are resistant to degradation by cellular hydrolases, DNases, RNases, and phosphodiesterases, but remain sensitive to prolonged exposure to low pH. The present studies evaluate the oral fractional bioavailability, stability, and efficacy of two