Transdermal iontophoretic delivery of triptorelin in vitro

Transdermal iontophoretic delivery of tr

✍ Schuetz, Yannic B. (author);Naik, Aarti (author);Guy, Richard H. (author);Vuarid 📂 Article 📅 2005 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 124 KB

The feasibility of delivering triptorelin ]LHRH) by transdermal iontophoresis was evaluated in vitro. Peptide electrotransport at different current densities and donor concentrations was measured across porcine ear skin. The concomitant delivery of an electroosmotic marker enabled calculation of the

Yannic B. Schuetz, Aarti Naik, Richard H

Yannic B. Schuetz, Aarti Naik, Richard H. Guy, Evelyne Vuaridel, Yogeshvar N. Kalia. Transdermal iontophoretic delivery of triptorelin in vitro. 94:2175-2182, 2005

📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 46 KB

The feasibility of delivering triptorelin ]LHRH) by transdermal iontophoresis was evaluated in vitro. Peptide electrotransport at different current densities and donor concentrations was measured across porcine ear skin. The concomitant delivery of an electroosmotic marker enabled calculation of the

In vitro transdermal iontophoretic deliv

In vitro transdermal iontophoretic delivery of leuprolide—mechanisms under constant voltage application

✍ Charu Kochhar; Georgios Imanidis 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

The transdermal iontophoretic delivery of Leuprolide, a nonapeptide LHRH agonist was studied with the aim of understanding the mechanisms of iontophoresis. Permeation studies were carried out at pH 4.5 and 7.2, at which the average ionic valence of the drug molecule was roughly 2 and 1, respectively

Mechanistic studies of the transdermal i

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro

✍ Oliver W. Ackaert; Jeroen Van Smeden; Jeroen De Graan; Durk Dijkstra; Meindert D 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

A characterization and optimization of the in vitro transdermal iontophoretic transport of 5-hydroxy-2-(N,N,-di-n-propylamino)tetralin (5-OH-DPAT) is presented. The utility of acetaminophen as a marker of electroosmotic flow was studied as well. The following parameters of iontophoretic transport of

Iontophoretic (transdermal) delivery of

Iontophoretic (transdermal) delivery of drugs: Overview of historical development

✍ Yie W. Chien; Ajay K. Banga 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB

Quantitative prediction of transdermal i

Quantitative prediction of transdermal iontophoretic delivery of arbutamine in humans with the in vitro isolated perfused porcine skin flap

✍ J. E. Riviere; P. L. Williams; R. S. Hillman; L. M. Mishky 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB

The use of the isolated perfused porcine skin flap (IPPSF), an alternative in vitro animal model, to predict the profile of the concentration of arbutamine in plasma samples from humans after transdermal iontophoretic administration of this novel catecholamine is described. The strategy involved adm