Transdermal fentanyl for the treatment of pain after major urological operations

✍ Scribed by K. A. Lehmann; C. Einnolf; H.-J. Eberlein; R. Nagel

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 476 KB
• Volume: 41
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00280100

✦ Synopsis

Transdermal fentanyl 75 micrograms/h (Fentanyl-TTS) was compared with placebo in a randomized double-blind study in the early postoperative period, using 50 patients recovering from major urological operations. Analgesic efficacy was individually titrated with intravenous fentanyl by means of a PCA pump (demand dose 34 micrograms, lockout time 5 min). The test systems were applied 8 h before anaesthesia and were left in situ for 24 h. During the PCA period (18.2 h) patients with Fentanyl-TTS required significantly less additional fentanyl (0.48 vs 0.93 micrograms.kg-1.h-1) and reported less pain than patients in the placebo-group. Patient acceptance was high in both groups. Side-effects were of only minor intensity and did not differ between the two groups. In particular, there was no case of clinically relevant respiratory depression.