Transcriptome at the time of hepatitis C virus recurrence may predict the severity of fibrosis progression after liver transplantation

✍ Scribed by Valeria Mas; Daniel Maluf; Kellie J. Archer; Amiee Potter; Jihee Suh; Ricardo Gehrau; Valeria Descalzi; Federico Villamil

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 443 KB
• Volume: 17
• Category: Article
• ISSN: 1527-6465
• DOI: 10.1002/lt.22309

✦ Synopsis

Allograft gene expression analysis may provide insights into the mechanisms involved in liver damage during hepatitis C virus recurrence (HCVrec) after orthotopic liver transplantation (OLT) and allow the identification of patients who have a higher risk of developing severe disease. Forty-three OLT recipients with hepatitis C virus (HCV) were evaluated. Genomewide gene expression analysis was performed with formalin-fixed, paraffin-embedded (FFPE) liver biopsy samples obtained from 21 OLT recipients with HCV at the time of clinical HCVrec, which was defined as increased alanine aminotransferase levels and detectable HCV RNA levels in serum. Patients were classified into 3 groups according to the severity of the fibrosis in the liver biopsies at 36 months post-OLT : group 1 (G1) for mild fibrosis (F0-F1), group 2 for moderate fibrosis (F2), and group 3 (G3) for severe fibrosis (F3-F4). No significant differences were observed between the groups with respect to Additional Supporting Information may be found in the online version of this article.