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Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells

✍ Scribed by Peter Morin Nissom; Arleen Sanny; Yee Jiun Kok; Yeo Thong Hiang; Song Hui Chuah; Tan Kher Shing; Yih Yean Lee; Tin Kam Wong; Wei-shou Hu; Miranda Yap Gek Sim; Robin Philp

Book ID
111640558
Publisher
Humana Press Inc
Year
2006
Tongue
English
Weight
404 KB
Volume
34
Category
Article
ISSN
1073-6085

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## Abstract Human recombinant erythropoietin (rHuEPO) was produced from Chinese hamster ovary (CHO) cells transfected with the human EPO gene. The cells were grown in batch cultures in controlled bioreactors in which the set‐points for dissolved oxygen varied between 3% and 200%. The cell‐specific