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Transcriptional suppression of estrogen receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

✍ Scribed by Yanan Tian; Sui Ke; Thresia Thomas; Robert J Meeker; Michael A Gallo


Book ID
117669043
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
433 KB
Volume
67
Category
Article
ISSN
0960-0760

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2,3,7,8-Tetrachlorodibenzo-p-dioxin rece
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The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dioxin, produces a diverse set of biological responses which, in some cases, reflects the altered expression of specific genes. An intracellular receptor protein binds TCDD saturably and with high affinity and mediates several