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Transcriptional repression in ES cells

✍ Scribed by Clara Y. Cheong; Thomas Lufkin

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
127 KB
Volume
110
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

The dynamics of embryonic stem cell pluripotency is orchestrated by an interplay of transcriptional and epigenetic regulation in a systematic and modular manner. While the ES cell stage is marked by multiple loci with bivalent chromatin marks that prepare genes for imminent activation on differentiation, this open chromatin conformation is tempered by repressive machinery that prevent premature expression of key developmental genes. This review serves to highlight key ES transcription factors and their known links to the epigenetic machinery via known protein complexes. J. Cell. Biochem. 110: 288–293, 2010. Β© 2010 Wiley‐Liss, Inc.

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