Activated brain microglia play a pivotal role in inflammatory and degenerative disorders, mediating immune function and producing toxic and trophic agents. We previously reported that microglia express neurotrophins and that neurotrophin-3 (NT-3) increases microglial proliferation and phagocytosis,
Transcriptional regulation of Trk family neurotrophin receptors
β Scribed by L. Lei; L. F. Parada
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 96 KB
- Volume
- 64
- Category
- Article
- ISSN
- 1420-682X
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Neurotrophins and their cognate receptors are critical to normal nervous system development. Trk receptors are high-affinity receptors for nerve-growth factor (trkA), brain-derived neurotrophic factor and neurotrophin-4/5 (trkB), and neurotrophin-3 (trkC). We examine the expression of these three ne
## Abstract Effects of 4βmethycatechol (4MC), a potent stimulator of nerve growth factor and brainβderived neurotrophic factor (BDNF) synthesis, on phosphorylation of cellular molecules in cultured rat cortical neurons were examined. 4MC stimulated tyrosine phosphorylation of various proteins of mo