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Transcriptional regulation of the TGF-β pseudoreceptor BAMBI by TGF-β signaling

✍ Scribed by Takashi Sekiya; Takeaki Oda; Ken Matsuura; Tetsu Akiyama

Book ID
116288746
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
230 KB
Volume
320
Category
Article
ISSN
0006-291X

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for