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Transcriptional Regulation of the GLAST/EAAT-1 Gene in Rat and Man

✍ Scribed by Unger, Tina; Lakowa, Nicole; Bette, Stefanie; Engele, Jürgen

Book ID
113063327
Publisher
Springer
Year
2012
Tongue
English
Weight
359 KB
Volume
32
Category
Article
ISSN
0272-4340

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## Abstract In the vertebrate CNS, glutamate transport predominantly occurs through the glutamate transporter subtype, GLT‐1/EAAT‐2, which prevails in astrocytes. GLT‐1/EAAT‐2 expression is impaired in many acute and chronic brain diseases, leading to increases in extracellular glutamate and subseq