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Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors

✍ Scribed by Marjan Shafaati; Riona O’Driscoll; Ingemar Björkhem; Steve Meaney

Book ID
116297819
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
201 KB
Volume
378
Category
Article
ISSN
0006-291X

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## Abstract Cytochrome P450 1A2 (CYP1A2) is constitutively expressed in the mouse liver, but the constitutive expression progressively declines to an undetectable level in isolated hepatocytes. In this study, CYP1A2 was induced in hepatocytes exposed to the histone deacetylase inhibitors trichostat