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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

✍ Scribed by Peterson, Pärt; Org, Tõnis; Rebane, Ana

Book ID: 109956013
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 450 KB
Volume: 8
Category: Article
ISSN: 1474-1741
DOI: 10.1038/nri2450

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## Background Evolutionary theories of aging propose that longevity evolves as a competition between reproduction and somatic maintenance for a finite pool of resources. Reproduction is thought to shorten lifespan by depleting resources from processes promoting somatic maintenance. Maternal yolk pr