Transcriptional effects of inhibiting epidermal growth factor receptor in keratinocytes
β Scribed by Gazel, Alix; Blumenberg, Miroslav
- Book ID
- 122520134
- Publisher
- Medknow Publications
- Year
- 2013
- Tongue
- Chinese
- Weight
- 376 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1027-8117
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The epidermal growth factor (EGF) receptor plays a central role in numerous aspects of keratinocyte biology. In normal epidermis, the EGF receptor is important for autocrine growth of this renewing tissue, suppression of terminal differentiation, promotion of cell survival, and regulation of cell mi
Transformed keratinocytes (SCC-4, SCC-15, SCC-12F2, SVK14) or normal keratinocytes which differ in their differentiation programme were used to study the regulation of EGF-receptor expression. The capacity of the cells to differentiate was modulated by changing the extracellular calcium concentratio
## Abstract Epidermal growth factor receptor (EGFR) plays a critical role in mediating ultraviolet (UV) irradiationβinduced signal transduction and gene expression in human keratinocytes. EGFR activation results from increased phosphorylation on specific tyrosine residues in the Cβterminal intracel