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Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

✍ Scribed by Zoltan Arany; Huamei He; Jiandie Lin; Kirsten Hoyer; Christoph Handschin; Okan Toka; Ferhaan Ahmad; Takashi Matsui; Sherry Chin; Pei-Hsuan Wu; Igor I. Rybkin; John M. Shelton; Monia Manieri; Saverio Cinti; Frederick J. Schoen; Rhonda Bassel-Duby; Anthony Rosenzweig; Joanne S. Ingwall; Bruce M. Spiegelman


Book ID
116372318
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
872 KB
Volume
1
Category
Article
ISSN
1550-4131

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Selenoprotein P (SeP), the major selenoprotein in plasma, is produced mainly by the liver, although SeP expression is detected in many organs. Recently, we reported stimulation of SeP promoter activity by the forkhead box transcription factor FoxO1a in hepatoma cells and its attenuation by insulin.