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Transcriptional analysis of doxorubicin-induced cytotoxicity and resistance in human hepatocellular carcinoma cell lines

✍ Scribed by Jin Wang; Judy Yuet-Wa Chan; Chi-Chun Fong; Chi-Hung Tzang; Kwok-Pui Fung; Mengsu Yang

Book ID: 111239143
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 671 KB
Volume: 29
Category: Article
ISSN: 0106-9543
DOI: 10.1111/j.1478-3231.2009.02081.x

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## Abstract Rodent cell lines can develop resistance to doxorubicin and methotrexate during hypoxic stress. This has so far not been observed in human tumor cell lines. The purpose of our communication is to show that doxorubicin and methotrexate resistance can also develop in human melanoma cells