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Transcriptional activation of Skp2 by BCR-ABL in K562 chronic myeloid leukemia cells

✍ Scribed by Jing-Yi Chen; Ming-Chung Wang; Wen-Chun Hung

Book ID
104041018
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
540 KB
Volume
33
Category
Article
ISSN
0145-2126

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Bcr-Abl-induced tyrosine phosphorylation
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✍ Jing-Yi Chen; Ming-Chung Wang; Wen-Chun Hung πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 227 KB

## Abstract Our previous study demonstrates that Bcr‐Abl fusion oncogene frequently found in chronic myeloid leukemia (CML) cells can up‐regulate Skp2 expression via transcriptional activation. However, Bcr‐Abl also modulates Skp2 protein stability in these cells. Treatment of Bcr‐Abl kinase inhibi