Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2
β Scribed by Hiroshi Kubota; Shuji Matsumoto; Shin-ichi Yokota; Hideki Yanagi; Takashi Yura
- Book ID
- 117111672
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 167 KB
- Volume
- 461
- Category
- Article
- ISSN
- 0014-5793
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Molecular mechanisms which underlie the heat shock response have commonly been analyzed using tissue culture systems, with less investigation of the intact mammal. In tissue culture, a temperature elevation of 5Β°C is required to activate mammalian heat shock transcription factor 1 (HSF1) to the DNA-
## Abstract Summary: Heat shock transcription factors (Hsfs) are major transactivators of heat shock protein (Hsp) genes in the response to stress stimuli, but are also thought to be involved in embryonic development and spermatogenesis. Among the three known mammalian Hsfs, Hsf1 is recognized as t