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Transcriptional activation by BRCA1

✍ Scribed by Chapman, Mark S.; Verma, Inder M.


Book ID
109796668
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
629 KB
Volume
382
Category
Article
ISSN
0028-0836

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## Abstract To better understand the alterations present in the group of the so‐called BRCAX tumors, we have used a cDNA microarray containing genes related to tumorigenesis and analyzed a series of 49 tumors consisting of 13 BRCA1, 14 BRCAX and 22 sporadic. We have confirmed that the BRCAX tumors

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## Abstract The global changes in gene expression induced by transient increased expression of full length BRCA1 as well as the spliced variant BRCA1~S~ were evaluated by cDNA expression array in a human non‐tumorigenic mammary epithelial cell line, MCF10A. Over 30 genes were identified that displa