Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1
โ Scribed by Ordway, Jared M; Williams, Katy; Curran, Tom
- Book ID
- 110068559
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 414 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
## Abstract We have previously shown that transcription of immediateโearly __cโfos__ protooncogene is becoming strongly repressed in rat embryo fibroblasts transformed by oncogenes __E1A__ and __cHaโras__, so that serum only slightly stimulated __cโfos__ transcription in these cells in contrast to
## Abstract Prolonged expression of activated __ras__ mutants resulted in both neoplastic transformation and suppression of serumโinduced cโ__fos__ expression in Rat1 fibroblasts. Expression of other serumโinducible genes, including cโ__jun__ and ฮฒโactin, was not suppressed in __ras__โtransformed R