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Transcription repression activity is associated with the type I isoform of the MMSET gene involved in t(4;14) in multiple myeloma

✍ Scribed by Katia Todoerti; Domenica Ronchetti; Luca Agnelli; Stefano Castellani; Silvia Marelli; Giorgio Lambertenghi Deliliers; Alberto Zanella; Luigia Lombardi; Antonino Neri


Book ID
108673426
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
246 KB
Volume
131
Category
Article
ISSN
0007-1048

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Multiple myeloma (MM) frequently shows overexpression of cyclin D1, either due to a t(11;14)(q13;q32) translocation, or in association with polysomy 11. The predominant expression of a cyclin D1 mRNA isoform lacking the 3'-untranslated region (Delta3'UTR) is associated with higher total cyclin D1 mR