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Transcription of somePHO genes inSaccharomyces cerevisiae is regulated by Spt7p

✍ Scribed by Nishimura, Ken; Yasumura, Kyoko; Igarashi, Kazuei; Harashima, Satoshi; Kakinuma, Yoshimi

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 170 KB
Volume: 15
Category: Article
ISSN: 0749-503X
DOI: 10.1002/(sici)1097-0061(199912)15:16<1711::aid-yea497>3.0.co;2-8

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✦ Synopsis

Spt7p is a new global transcription factor in Saccharomyces cerevisiae (Gansheroff et al., 1995). We report here that the activities of high affinity phosphate transport and acid phosphatase in particular were decreased in a spt7 null mutant. Northern blot experiments revealed that transcription of the PHO84 and PHO5 genes was impaired in this mutant; expression of the PHO regulatory genes, PHO4 and PHO2, was normal. Spt7p is thus linked with expression of several structural genes of the PHO regulon in yeast.

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