Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion

Interallelic class switch recombination

Interallelic class switch recombination can reverse allelic exclusion and allow trans-complementation of an IgH locus switching defect

✍ Hei-Lanne Dougier; Stéphane Reynaud; Eric Pinaud; Claire Carrion; Laurent Delpy; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB

## Abstract The predominant path of immunoglobulin class switch recombination follows the paradigm of intra‐chromosomal deletion enabling expression of another heavy chain instead of µ and δ. This was, however, challenged by observations of inter‐allelic class switch recombination in rabbit or mous