Transcription of PRDM1, the master regulator for plasma cell differentiation, depends on an SP1/SP3/EGR-1 GC-box

Differential role for Sp1/Sp3 transcript

Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes

✍ Alfredo Pagliuca; Pasquale Gallo; Luigi Lania 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB 👁 2 views

Cyclin-dependent kinase inhibitors play a significant role in cell cycle progression and in cellular differentiation and their expression is regulated in different cellular settings. GC-rich regions in the promoter sequences of the cyclin-dependent kinase inhibitor genes p15INK4B and p21CIP1/WAF1 me