𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transcription-Inhibition and Antitumor Activities of N-Alkylated Tetraazacyclododecanes

✍ Scribed by Xiao-Qin Xiong; Feng Liang; Li Yang; Xiao-Lin Wang; Xiang Zhou; Cong-Yi Zheng; Xiao-Ping Cao

Book ID
101773414
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
241 KB
Volume
4
Category
Article
ISSN
1612-1872

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of alkyl‐substituted tetraazacyclododecane congeners were synthesized, and their antitumor activities towards human HeLa cells as well as their effect on the in vitro transcription with T7 RNA polymerase were investigated. A structure–activity‐relationship (SAR) study identified the most‐active congeners as those with medium alkyl‐chain lengths. Three compounds, 5–7, were found to exhibit significant biological activities, with IC~50~ values towards HeLa cells in the low‐micromolar range.

📜 SIMILAR VOLUMES

Cell proliferation inhibition and antitu
Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds
✍ Biplob Koch; Tushar S. Basu Baul; Anupam Chatterjee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

Diorganotin(IV) compounds, R 2 SnCl 2 are often tetrahedral, and structurally resemble the active platinum compounds, i.e. cisplatin, and consequently a large number of such complexes have been tested for antitumor activity. A structural correlation with biological activity for diorganotin(IV) compl

Antitumor agents 273. Design and synthes
Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents
✍ Takashi Kozaka; Kyoko Nakagawa-Goto; Qian Shi; Chin-Yu Lai; Ernest Hamel; Kennet 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 313 KB

As a part of our continuing study of colchicinoids as therapeutically useful antitumor drugs, thiocolchicine derivatives, including their phosphate and other water soluble salts, were synthesized and evaluated for inhibition of tubulin polymerization and for in vitro cytotoxicity. Three compounds, 7