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Transcription factor Sp3 is silenced through SUMO modification by PIAS1

✍ Scribed by Sapetschnig, Alexandra; Rischitor, Grigore; Braun, Harald; Doll, Andreas; Schergaut, Marion; Melchior, Frauke; Suske, Guntram


Book ID
111749818
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
293 KB
Volume
21
Category
Article
ISSN
0261-4189

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,