## Abstract Tamoxifen, a nonsteroidal antiβestrogen, is a potent genotoxic hepatocarcinogen in rats, with both tumor initiating and promoting properties. Recently it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations and t
Transcription factor-induced epigenetic reprogramming
β Scribed by Hochedlinger, Konrad
- Book ID
- 109846940
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 240 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0007-0610
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Epigenetic information, not DNA sequence, distinguishes different cell types within a multicellular organism. The molecular nature of epigenetic information specifying differentiated cell types is unknown. However, it must be stable over time and mitotically heritable. In this paper, steady-state le
## Abstract Ectopic expression of a defined set of transcription factors chosen from Oct3/4, Sox2, cβMyc, Klf4, Nanog, and Lin28 can directly reprogram somatic cells to pluripotency. These reprogrammed cells are referred to as induced pluripotent stem cells (iPSCs). To date, iPSCs have been success