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Transcription Factor Ets-1 Mediates Ischemia- and Vascular Endothelial Growth Factor-Dependent Retinal Neovascularization

✍ Scribed by Daisuke Watanabe; Hitoshi Takagi; Kiyoshi Suzuma; Izumi Suzuma; Hideyasu Oh; Hirokazu Ohashi; Seiji Kemmochi; Akiyoshi Uemura; Tomonari Ojima; Eri Suganami; Noriko Miyamoto; Yasufumi Sato; Yoshihito Honda

Book ID: 117021827
Publisher: American Society for Investigative Pathology
Year: 2004
Tongue: English
Weight: 408 KB
Volume: 164
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63741-8

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## Abstract Transcription factor Ets‐1 is induced in endothelial cells (ECs) by angiogenic factors, and promotes angiogenesis by inducing angiogenesis‐related genes such as MMPs and integrin β3. Here, we examined the effect of Ets‐1 on apoptosis in ECs. Overexpression of Ets‐1 in human umbilical ve

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