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Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo

โœ Scribed by Ahn, J D; Morishita, R; Kaneda, Y; Kim, H J; Kim, Y D; Lee, H J; Lee, K U; Park, J Y; Kim, Y H; Park, K K

Book ID
110039529
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
377 KB
Volume
11
Category
Article
ISSN
0969-7128

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## Abstract Transcription factor Spโ€1 is an important fibrogenic factor that is involved in the pathogenesis of diabetic nephropathy. In this study, we examined the effect of Sp1 decoy oligodeoxynucleotides (ODNs) on the extracellular matrix (ECM) gene expression in cultured rat mesangial cells (RM