Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression

The functional −443T/C osteopontin promo

The functional −443T/C osteopontin promoter polymorphism influences osteopontin gene expression in melanoma cells via binding of c-Myb transcription factor

✍ Julia Schultz; Peter Lorenz; Saleh M. Ibrahim; Günther Kundt; Gerd Gross; Manfre 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB

## Abstract In the present report, the possible role of a recently described functional polymorphism of the osteopontin (OPN) promoter at position −443 (−443T/C) for OPN expression in melanoma cells was addressed. As shown by __real‐time__ PCR analysis, melanoma metastases that were homozygous for