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Transcranial direct current stimulation for the treatment of focal hand dystonia

✍ Scribed by David H. Benninger; Mikhail Lomarev; Grisel Lopez; Natassja Pal; David A. Luckenbaugh; Mark Hallett

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 184 KB
Volume: 26
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.23691

No coin nor oath required. For personal study only.

✦ Synopsis

The treatment of writer's cramp, a task-specific focal hand dystonia, needs new approaches. A deficiency of inhibition in the motor cortex might cause writer's cramp. Transcranial direct current stimulation modulates cortical excitability and may provide a therapeutic alternative. In this randomized, double-blind, sham-controlled study, we investigated the efficacy of cathodal stimulation of the contralateral motor cortex in 3 sessions in 1 week. Assessment over a 2-week period included clinical scales, subjective ratings, kinematic handwriting analysis, and neurophysiological evaluation. Twelve patients with unilateral dystonic writer's cramp were investigated; 6 received transcranial direct current and 6 sham stimulation. Cathodal transcranial direct current stimulation had no favorable effects on clinical scales and failed to restore normal handwriting kinematics and cortical inhibition. Subjective worsening remained unexplained, leading to premature study termination. Repeated sessions of cathodal transcranial direct current stimulation of the motor cortex yielded no favorable results supporting a therapeutic potential in writer's cramp.

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