Transannular Ring Closure of a 1,8-Diazacyclotetradeca-3,5,10,12-tetrayne to a Tricyclic System with a Central Cyclooctatetraene Ring
✍ Scribed by Rolf Gleiter; Kirstin Hövermann; Birgit Esser; Arkasish Bandyopadhyay
- Book ID
- 102171302
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 222 KB
- Volume
- 2009
- Category
- Article
- ISSN
- 1434-193X
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A concise synthesis of the macrocyclic vinylbutenolide 19 is described, based on a facile RCM reaction of the substrates 16/18. Treatment of 19 with TFA containing water led to the 5,6,7-tricyclic compound 27, in a single step, in >90% yield, rather than to the alternative ring system 23 found in pl
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