Transamination by Polymeric Enzyme Mimics

✍ Scribed by Wenjun Zhou; Lei Liu; Ronald Breslow

• Book ID: 102256198
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 87 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390300

✦ Synopsis

Abstract

Pyridoxamine was linked to a series of polyethylenimines (PEIs) with M~n~=600, 1800, 10,000, and 60,000, both simply permethylated and with additional attached dodecyl chains. They were examined in the transamination of pyruvic acid and of phenylpyruvic acid, and showed MichaelisMenten behavior. The values of k~2~ and of K~M~ determined showed only small variations with polymer size. Thus, the previously reported strong advantage of pyridoxamines attached to the M~n~=60,000 PEI, relative to simple pyridoxamine alone, is seen to almost the same extent with the smaller PEIs.