Transactivation of the IGFBP-2 promoter in human tumor cell lines
✍ Scribed by Martin W. Elminger; Mathias Bell; Burkhardt S. Schüett; Markus Langkamp; Eiji Kutoh; Michael B. Ranke
- Book ID
- 117462649
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 296 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0303-7207
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Insulin-like growth factors (IGF-I and -II) play an active role in cell proliferation. In biological fluids, they are non-covalently bound to high-affinity binding proteins (IGFBPs), at least 6 species of which have been identified to date, but with poorly defined functions. One of these IGFBPs, IGF
## Abstract The tumor promoter TPA (12‐0‐tetradecanoyl‐phorbol‐13‐acetate) efficiently induces the synthesis of Epstein‐Barr virus (EBV) antigens in EBV‐genome‐harboring human lymphoblastoid cells. We attempted to obtain information on the binding of TPA to cells and on the relationship between TPA