Transactivation of the epidermal growth factor receptor (EGFR) mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells
β Scribed by Cheng, Kunrong; Zimniak, Piotr; Raufman, Jean-Pierre
- Book ID
- 123169366
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 255 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cellβsurface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcriptionβpolymerase chain reaction
Human colon cancer (Moser) cells produce and secrete epidermal growth factor (EGF) and respond to EGF via an autocrine/paracrine mode through the cell surface EGF receptor (EGFR). In this report we show that EGF promotes the malignant behavior of the Moser cells in vitro in terms of growth in soft a