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trans -Hexahydrobenzoxazolidinones in the Enantioselective Synthesis of β 2 -Amino Acids Containing Proteinogenic Side Chains

✍ Scribed by Bandala, Yamir; Reyes-Rangel, Gloria; Obregón-Zúñiga, Arturo; Cruz-Hernández, Carlos; Corzo, Gerardo; Juaristi, Eusebio


Book ID
121787125
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
677 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Catalytic asymmetric synthesis of the do
✍ Pawel Dziedzic; Jan Vesely; Armando Córdova 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 182 KB

A highly enantioselective catalytic route to protected b-amino-a-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected aoxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr an