trans-4-amino-3-hydroxypiperidines. Regio- and stereoselective synthesis
β Scribed by I. S. Veselov; I. V. Trushkov; N. S. Zefirov; G. V. Grishina
- Book ID
- 111465082
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2009
- Tongue
- English
- Weight
- 310 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1070-4280
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π SIMILAR VOLUMES
A simple and highly C3 selective ring-opening method for 3,4-epoxypiperidines has been developed. We also describe a practical improvement of the C4 selective ring-opening method using the same N-alkyl substituted 3,4-epoxypiperidines. This method provides access to pharmaceutically relevant trans-3
A piperidinyl aziridine underwent alcoholic nucleophilic addition with alcohols to result in corresponding trans 3-amino-4-substituted piperidines. The addition reaction was catalyzed by BF 3 β’OEt 2 in excellent regio-and stereoselectivity. The application of this method was extended to the addition