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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

✍ Scribed by Kagan, Jonathan C; Su, Tian; Horng, Tiffany; Chow, Amy; Akira, Shizuo; Medzhitov, Ruslan

Book ID: 109923462
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 594 KB
Volume: 9
Category: Article
ISSN: 1529-2908
DOI: 10.1038/ni1569

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## Abstract Toll‐like receptor 3 (TLR3) recognizes double‐stranded RNA and induces type I interferon (IFN)‐mediated antiviral immunity against a number of viral infections. Type III IFN (IFN‐λ) is a newly identified antiviral cytokine that has biological functions similar to those of type I IFNs. W