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Trajectory of age-associated structural changes in early-onset Alzheimer's disease, for the Alzheimer's Prevention Initiative

✍ Scribed by Adam Fleisher; Yakeel Quiroz; Kewei Chen; Laura Jakimovich; Madelyn Gutierrez; Jessica Langbaum; Auttawut Roontiva; Pradeep Thiyyagura; Xiaofen Liu; Wendy Lee; Napatkamon Ayutyanont; Mark Nishimura; Stephanie Parks; Sergio Alvarez; Claudia Munoz; Victoria Tirado; Margarita Giraldo; Ken Kosik; Pierre Tariot; Francisco Lopera; Eric Reiman


Book ID
118468157
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
69 KB
Volume
8
Category
Article
ISSN
1552-5260

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## Abstract Regional and global cerebral atrophy are inevitable features of Alzheimer's disease (AD). We assessed volumes and atrophy rates of brain structures in patients with familial AD during the period that they developed symptoms. Five patients with presymptomatic AD and 20 controls had two o