Timing of ibuprofen use and bone mineral
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Wendy M Kohrt; Daniel W Barry; Rachael E Van Pelt; Catherine M Jankowski; Pamela
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Article
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2010
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American Society for Bone and Mineral Research
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English
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Prostaglandins (PGs) are essential signaling factors in bone mechanotransduction. In animals, inhibition of the enzyme responsible for PG synthesis (cyclooxygenase) by nonsteroidal anti-inflammatory drugs (NSAIDs) blocks the bone-formation response to loading when administered before, but not immedi