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Trafficking of receptor tyrosine kinases to the nucleus

✍ Scribed by Graham Carpenter; Hong-Jun Liao

Book ID: 113955811
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 530 KB
Volume: 315
Category: Article
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2008.09.027

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Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the g-phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that aect cell p