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Trafficking of major histocompatibility complex class II molecules in human B-lymphoblasts deficient in the AP-3 adaptor complex

✍ Scribed by Steve Caplan; Esteban C Dell’Angelica; William A Gahl; Juan S Bonifacino


Book ID
108408077
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
72
Category
Article
ISSN
0165-2478

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## Abstract We show that major histocompatibility complex (MHC) class II molecules on B cells transmit signals which regulate adhesion in a negative manner. Engagement of MHC class II molecules with antibodies results in detachment of B cells previously bound to interferon‐γ‐activated human umbilic