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Trafficking of amyloid β-precursor protein products C83 and C99 on the endocytic pathway

✍ Scribed by James Hare

Book ID: 116300833
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 682 KB
Volume: 401
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.09.033

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas