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Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts

✍ Scribed by Koichi Shimada; Kyoko Ikeda; Koichi Ito

Book ID: 116299332
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 416 KB
Volume: 390
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.10.048

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## Abstract Inhibition of osteoblast‐mediated mineralization is one of the major catabolic effects of parathyroid hormone (PTH) on bone. Previously, we showed that PTH induces matrix γ‐carboxyglutamic acid (Gla) protein (MGP) expression and established that this induction is critical for PTH‐mediat