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TRAF1 Is a Negative Regulator of TNF Signaling: Enhanced TNF Signaling in TRAF1-Deficient Mice

✍ Scribed by Erdyni N Tsitsikov; Dhafer Laouini; Ian F Dunn; Tatyana Y Sannikova; Laurie Davidson; Frederick W Alt; Raif S Geha

Book ID
117723117
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
352 KB
Volume
15
Category
Article
ISSN
1074-7613

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## Abstract Matrix metalloproteinases (MMPs), in particular MMP‐9, have been shown to be induced by cytokines, including TNF‐α and contributes to airway inflammation. However, the mechanisms underlying TNF‐α‐induced MMP‐9 expression in human A549 cells remain unclear. Here, we report that TNF‐α‐ind