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Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

✍ Scribed by Alexander M. Kulminski; Irina Culminskaya; Svetlana V. Ukraintseva; Konstantin G. Arbeev; Liubov Arbeeva; Deqing Wu; Igor Akushevich; Kenneth C. Land; Anatoli I. Yashin

Book ID
111199742
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
210 KB
Volume
10
Category
Article
ISSN
1474-9718

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## Abstract ## Objective This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein‐E epsilon 4 allele (__APOE__ Ξ΅4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic g