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Tracking spindle checkpoint signals from kinetochores to APC/C

✍ Scribed by Jia, Luying; Kim, Soonjoung; Yu, Hongtao

Book ID
120207061
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
955 KB
Volume
38
Category
Article
ISSN
0968-0004

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## Abstract Cdc20, an activator of the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase, initiates the destruction of key mitotic regulators to facilitate mitosis, while it is negatively regulated by the spindle assembly checkpoint (SAC) to prevent premature anaphase entry. Activation