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Tracing and characterization of the low-avidity self-specific T cell repertoire

✍ Scribed by Karin E. de Visser; Tanina A. Cordaro; Dimitris Kioussis; John B. A. G. Haanen; Ton N. M. Schumacher; Ada M. Kruisbeek


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
169 KB
Volume
30
Category
Article
ISSN
0014-2980

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Myelin basic protein (MBP) is a well-characterized autoantigen potentially involved in the pathogenesis of the most common human demyelinating disease of the central nervous system (CNS), multiple sclerosis (MS). It is known that MBP-specific T-cell responses differ widely among different individual