Trace detection of hormones and sulfonamides in viscous cosmetic products by neutral desorption extractive electrospray ionization tandem mass spectrometry
✍ Scribed by Yan Liu; Xinglei Zhang; Yongzhong Ouyang; Zhong Hu; Li Ma; Jinghua Zhang; Jinming Lin; Huanwen Chen
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 277 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.1944
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✦ Synopsis
Abstract
A sensitive method based on a geometry‐independent neutral desorption (GIND) in combination with extractive electrospray ionization mass spectrometry (EESI‐MS) has been developed for fast detection of illicit additives such as sulfonamides and hormones in highly viscous cosmetic products. The method gave a low limit of detection (LOD) (in the range of 0.001–1 ng/g), acceptable relative standard deviation (RSD = 6.8–11.4%) and reasonable recovery (87–116%) for direct measuring of nine types of hormones and sulfonamides in the cosmetic products. The average measurement time for two types of samples was less than 1 min. Trace amounts of analytes in commercial cosmetic products have been quantitatively detected, without any sample pretreatment. The experimental results showed that non‐volatile illicit additives such as sulfonamides and hormones could be sensitively liberated using the GIND device for quantitative detection from the highly viscous cosmetic products, demonstrating that GIND‐EESI‐MS is a promising tool for high throughput, sensitive and quantitative analysis of highly complex viscous samples. Copyright © 2011 John Wiley & Sons, Ltd.