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TP53and p53 statuses and their clinical impact in diffuse low grade gliomas

✍ Scribed by Gillet, Emeline; Alentorn, Agusti; Doukouré, Brahima; Mundwiller, Emeline; van Thuij, Hinke; Reijneveld, Jaap C.; Medina, José Alfonso Meza; Liou, Amélie; Marie, Yannick; Mokhtari, Karima; Hoang-Xuan, Khê; Sanson, Marc; Delattre, Jean-Yves; Idbaih, Ahmed

Book ID
121841891
Publisher
Springer US
Year
2014
Tongue
English
Weight
986 KB
Volume
118
Category
Article
ISSN
0167-594X

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Thirty-eight WHO grade II astrocytomas and I0 malignant recurrent gliomas in these patients were examined for the presence of TP.53 alterations. Seventeed38 low grade astrocytomas and 6/10 malignant recurrent tumors harbored mutations of the gene detected by SSCP analysis and direct sequencing of PC