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TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

✍ Scribed by Hussain, S P; Schwank, J; Staib, F; Wang, X W; Harris, C C

Book ID: 110072276
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 472 KB
Volume: 26
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1210279

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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGG→AGT at codon 249, Arg→Ser) has been identified as a hotspot in HCCs from such areas,

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